Hesperidin Methyl Chalcone
 

Methyl hesperidine is a methylated derivative of citrus flavonoid hesperidine. The methylated derivatives are of two types with ring closed during methylation and ring open during methylation, which respectively yields methylhesperidine and hesperidine methyl chalcone. In contrast to the hesperidine , the methylated derivatives are totally water soluble against total insoluble behavior of hesperidine, which makes it an effective source of water soluble flavonoids requirement making its use versatile in netraceuticals,cosmetics and beverages.

 
  • Molecular Formula : C29H36O15
  • Molecular Weight : 624.59 g/mol
  • CAS No. : 24292-52-2
  • Character : Light yellow crystalline powder, slightly smell,slightly bitter taste, soluble in water and ethanol
 

While hesperidin itself is not very water-soluble, hesperidin methyl chalcone (HMC) is highly water-soluble, allowing for greater absorption of the molecule in the gastrointestinal tract. As with all flavonoids, HMC is an antioxidant. Hesperidin also supports eye health and has blood vessel-stabilizing effects.

 

Hesperidin methyl chalcone is a compound derived from hesperidin. Hesperidin is an antioxidant bioflavonoid found in large quantities in citrus fruits. Most people get some hesperidin and other bioflavonoids naturally through diet. People who are deficient in hesperidin can experience abnormal capillary leakiness, leg aches and leg swelling. Hesperidin and derivatives like hesperidin methyl chalcone strengthen and protect capillaries and small veins so they are less likely to leak fluid into the surrounding tissue.

 

Hesperidin methyl (chalcone) supports and protects the integrity of the vascular system with particular activity in the capillaries and veins. Hesperidin methyl (chalcone) has been shown to help strengthen capillaries by increasing capillary resistance and decreasing capillary permeability. Increased venous motility, tone, and the ability of vessels to dilate are also enhanced by hesperidin methyl (chalcone).

 

One study showed that hesperidin methyl chalcone in combination with other ingredients reduced leg tightness and swelling in people with chronic venous insufficiency and varicose veins. There is also some evidence that taking hesperidin methyl chalcone as a dietary supplement reduces hot flashes in women going through menopause. Cosmetic manufacturers add hesperidin methyl chalcone to products formulated to reduce dark circles under the eyes, based on the idea that it strengthens the walls of blood vessels.

 

Because hesperidin methyl chalcone has antioxidant activity, it is also an ingredient formulated in some anti-aging products including anti-aging night creams, moisturizers, sunscreens and body lotions. Antioxidants help to protect skin cells against free radicals produced by exposure to sunlight and pollutants in the environment. Most research showing benefits of hesperidin methyl chalcone have used oral supplements. Less research has focused on its effects topically.

 

Hesperidin methyl chalcone appears to be safe when used as a dietary supplement. As a topical agent, it hasn't been evaluated for safety by an industry panel, although there are no reports of contact dermatitis or allergic reactions in the literature. However, people with sensitive skin may experience some tingling and redness when they use it.

 

While hesperidin itself is not very water-soluble, hesperidin methyl chalcone (HMC) is highly water-soluble, allowing for greater absorption of the molecule in the gastrointestinal tract. As with all flavonoids, HMC is an antioxidant. Hesperidin also supports eye health and has blood vessel-stabilizing effects.

 

Hesperidin methyl chalcone is widely used in South-Africa, USA, EU, not only in pharmaceutical but also in dietary supplement and cosmetic products.