Hesperidin is a flavanone diglycoside that is principally found in citrus fruit. It is a flavonoid derived from citrus fruits (lemons and oranges).
- Hesperetin 7-rhamnoglucoside, hesperetin-7-rutinoside
- Molecular weight : 610
- Formula : C28H34O15
- Source : Citrus Sinesis Fruits
- 10% / 15% / 25% / 35% / 50% / 80% / 85% Light brown to beige colored powder insoluble in aqeous systems.
Hesperidin has antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions. Hesperdin can inhibit following enzymes: phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase.
Hesperidin improves the health of capillaries by reducing the capillary permeability. Many experts believe flavonoids like hesperidin have a synergistic activity with vitamin C. Hesperidin may also increase the strength of veins and capillaries. In addition, hesperidin can reduce histamine release from mast cells by strengthening the cell membrane (mast cells are blood cells that contain granules of histamine and other substances).
Hesperidin is used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti-cancer activity of hesperidin could be explained by the inhibition of polyamine synthesis.
A study 'Hesperidin, a citrus flavonoids, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice' by Hiroshige Chiba et al (J. Nutrition, June 2003) showed that hesperidin added to the died not only lowered serum and hepatic cholesterol, but also inhibited bone loss by decreasing osteoclast number in ovariectomized mice. The molecular mechanism of the inhibitory effect of hesperidin on bone resorption is not clear.