Grapeseed extract might be useful for lowering LDL cholesterol, varicose veins, atherosclerosis (hardening of the arteries), high blood pressure. Flavonoids found in red wine have been reported to protect the heart. They may inhibit the oxidation of LDL cholesterol. (LDL oxidation which can lead to hardening of the arteries or atherosclerosis). Studies have demonstrated a relationship between flavonoid intake (from foods) and reduced risk of death from coronary heart disease. A recent study shows that a particular polyphenol in red grape skins, resveratrol, inhibits platelet aggregation and is the component responsible for red wine's health benefits. Resveratrol is found in the skin of grapes.